The Cancer Epigenetics and Biology Program- IDIBELL Foundation organises the meeting IDIBELL Cancer Conferences (ICC) on Mouse Models of Cancer. The confirmed invited speakers are international leaders in their fields. The goals of the meeting are 1) Discussion of the state of the art in mouse models of cancer and the latest advances in that field. 2) Facilitate the knowledge transfer between researcher and set-up new collaborations. 3) Promote the researchers interchange at international level. The meeting will be open to established scientist, PhD student and postdoctoral scientists interested in mouse models in cancer research.

The meeting will take place at the Hesperia Convention Center at L'Hospitalet de Llobregat (Barcelona). It will begin on Thursday morning, October 7th, 2010, and will conclude on Friday afternoon, October 8th, 2010. The ICC on Mouse Models of Cancer will host approximately 125 attendees. Since the amount of participants will not exceed 125 participants early registration is strongly recommended.

The schedule of the meeting includes 16 plenary conferences (30 min) organised in 4 different sessions. The attendants are encouraged to present their work in poster communications. The scientific committee that organises this meeting will select a reduced number of these communications to be presented as short talks (15 min). The summaries of the conferences, short talks and poster communications will be published in the abstract book of the congress.


Preliminary programme



L’Hospitalet de Llobregat (Barcelona)


October 7th.


8:00-9:00 Registration

9.00-9:30 Welcome and short talk organizers

SESSION I: Molecular Basis of Cancer


Chairman: Doug Hanahan


9:30 -10:00  Maria Blasco. Spanish National Cancer Research Center (CNIO), Spain.

“A telomerase intervention in adult/old mice extends health-span and longevity in the absence of cancer”


10:00-10:30 Mariano Barbacid. Spanish National Cancer Research Center (CNIO), Spain.

Targeting Ras signaling pathways in cancer”


10:30-10:45  Ferdinandos Skoulidis. University of Cambridge, UK.

“Germline Brca2 heterozygosity promotes KrasG12D –driven carcinogenesis in a murine model for familial pancreatic cancer”


10:45-11:00  Clotilde Costa. CIEMAT, Spain.

“Spontaneous squamous cell carcinoma in mouse epidermis mediated by the deregulation of Rb/E2F pathway”


11:00-11:30  COFFEE BREAK


11:30-12:00  Gerard Evan. University of Cambridge, UK.

“Deconstructing oncogenesis and tumour suppression”


12:00-12:15 Eva González Suárez. Bellvitge Biomedical Research Institute (IDIBELL), Spain.

“RANK ligand mediates progestin induced mammary epithelial proliferation and carcinogenesis”


12:15-12:30  Rama Khokha. Ontario Cancer Institute, Canada.

“RANKL as an oncogenic effector of the bone tumor suppressor Prkar1a”


12:30-12:45  Laurent Lê Cam. Institute for Cancer Research of Montpellier, France.

“The E4F1 protein is required for cell survival of leukemic cells”




SESSION II. Stem Cells and Cancer


Chairman: Jos Jonkers


14:30-15.00  Michael Clarke. Institute for Stem Cell Biology and Regenerative Medicine, USA.

“Regulation of self renewal in normal stem cells & cancer”


15.00-15:30 Marina Glukhova. Institute Curie Research Center, France.

“Myc, mammary stem cells and tumorigenesis”


15:30-15:45   Eva Vlug. Hubrecht Institute, The Netherlands.

“Functional analysis of adherens junction complex members using mouse model of tumor development and progression”.


15:45-16:15 COFFEE BREAK


16:15-16:45   Fiona Watt. Cambridge Research Institute, UK.

“Stem cells in mammalian epidermis”


16:45-17:00 Purificación Muñoz. Bellvitge Biomedical Research Institute (IDIBELL), Spain.

“Epidermal stem cells dynamics in mouse skin tumor initiation and progression”


17:00-18:00 POSTER SESSION I




20:00 DINNER


October 8th.

Session III. Tumor Progression, Invasion and Metastasis


Chairman: Mariano Barbacid


9:00 -9:30   Gerhard Christofori. University of Basel, Switzerland.

“News from the invasive cancer front”


9:30-10:00 Douglas Hanahan. School of Life Sciences, ISREC, Switzerland.

     “Polymorphic genetic control of invasion”


10:00-10:15  Jesus Perez Losada. IBMCC de Salamanca, Spain.

“Genetic Dissection of an Erbb2/cNeu Breast Cancer Mouse Model”



10:15-10:45 COFFEE BREAK


10:45-11:15  Alan Clarke. Cardiff School of Sciences, UK.

“Modifying Wnt driven murine models of colorectal cancer”.


11:15-11:45 Erwin Wagner. Spanish National Cancer Research Center     (CNIO), Spain.

“Functions of AP-1 (Fos/Jun) in cancer development”


11:45-12:15  Robert Hoffman. University of California, USA.

“Orthotopic metastatic mouse models expressing fluorescent proteins for imaging metastasis at the macro and cellular level in real time”


12:15-12.30  Evelyne Beerling, Hubrecht Institute, The Netherlands.

“Intravital imaging of the onset of breast cancer metastasis”.


12:30-14:30   POSTER SESSION + LUNCH


SESSION IV.  Experimental Therapeutics

Chairman: Gerhard Christofori


14:30-15:00 Jos Jonkers. The Netherlands Cancer Institute (NKI), The Netherlands.

“Targeting homologous recombination deficiency in genetically engineered mouse models of BRCA-associated breast cancer”


15:00-15:30  Alberto Villanueva. Catalan Institute of Oncology (ICO), Spain.

“Generation of orthotopic nude mice models of testicular germ cell tumors and epithelial ovarian cancer for the study of cisplatin resistance”


15:30-16:00 David Tuveson. Cambridge Research Institute, UK.

“Modelling Pancreatic Cancer Medicine” 


16:00-16:15  Hans-Guido Wendel. Sloan-Kettering Institute, USA.

“The soluble Eph-receptor A7 is a tumour suppressor gene in follicular lymphoma and readily restored for therapy”.


16:15 - Concluding Remarks by Manel Esteller and Cocktail


ICC on Mouse Models of Cancer 2010 / Cancer Epigenetics and Biology Program
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